Dr Gary Fettke - Nutrition and cancer – Time to rethink



Nutrition and cancer â?? Time to rethink
Dr Gary Fettke

In 1931 Otto Warburg received the Nobel Prize for showing that cancer cells have an absolute requirement to use glucose for their energy requirements since they lack proper mitochondrial function for oxidizing fats. This suggests that nutritional factors in particular low or high carbohydrate diets might influence cancer outcomes differently. In my presentation I will present the evidence showing that certain cancers may be carbohydrate-dependant and may be positively influenced by the ingestion of low carbohydrate ketogenic diets which reduce the provision of glucose to the tumour cells.

Cancer as a metabolic disease
Seyfried T N et al. Carcinogenesis 2013;carcin.bgt480
http://carcin.oxfordjournals.org/cont...

Cancer Statistics, Trends, and Multiple Primary Cancer Analyses from the Surveillance, Epidemiology, and End Results (SEER) Program
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Fouche FP: Freedom of Negro Races from Cancer, Br Med J. 1923 Jun
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Renehan G et al. Obesity and Cancer: Physiological and biological mechanisms. Archives of Physiology and Biochemistry, 2 2008; 114(1): 71-83
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Giovannucci et al. Diabetes and cancer: a consensus report. CA Cancer J Clin 2010;60:207-221
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Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Vander Heiden et al. Science 2009; science. 1160809
http://www.ncbi.nlm.nih.gov/pubmed/19...
Cancer cells metabolically â??fertilizeâ? the tumor microenvironment with hydrogen peroxide, driving the Warburg effect
Lisanti et al. Cell Cycle, 2011; 10(15); 2504-2520
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Chan et al, Are we ready to recommend aspirin for the prevention of cancer? Lancet. Apr 28,2012; 379(9826): 1569-1571
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Decensi et al, Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res, 2010 Nov;3(11):1451-61
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Lee et al, Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese. BMC Cancer. 2011;11:20
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Lv M, Zhu X, Wang H, Wang F, Guan W (2014) Roles of Caloric Restriction, Ketogenic Diet and Intermittent Fasting during Initiation, Progression and Metastasis of Cancer in Animal Models: A Systematic Review and Meta-Analysis. PLoS ONE 9(12): e115147. doi:10.1371/journal.pone.0115147
http://journals.plos.org/plosone/arti...
Schmidt et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial. Nutrition & Metabolism 2011, 8:54
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Fine et al. Nutrition, Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. 28 (2012) 1028-1035
http://www.ncbi.nlm.nih.gov/pubmed/22...
Rieger et al. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int Journ Oncology 44: 1843-1852, 2014
http://www.ncbi.nlm.nih.gov/pmc/artic...
Champ, Volek et al. 2014. Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. Jour Neurooncology DOI 10.1007/s11060-014-1362-0
http://www.ncbi.nlm.nih.gov/pubmed/24...
Human Clinical Trials
https://clinicaltrials.gov/ct2/result...
Raffaghello et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high dose chemotherapy. PNAS. 2008
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Klement and Champ. 2014 Calories, carbohydrates, and cancer therapy with radiation: exploiting the five Râ??s through dietary manipulation. Cancer Metastasis Rev. 2014; 33(1): 217â??229
http://www.ncbi.nlm.nih.gov/pubmed/24...
Novotny et al. A pessimistic explanatory style is prognostic for poor lung cancer survival. Jour Thoracic Oncology 2010 5(3):326-32
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Popkin et al. 2010,. Does hunger and satiety drive eating anymore? Increasing eating occasions and decreasing time between eating occasions in the United States Am J Clin Nutrition, 91: 1342-1347
http://www.ncbi.nlm.nih.gov/pubmed/20...
No Fructose
http://www.nofructose.com/

Video Length: 46:33
Uploaded By: Karen Thomson
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